Chemical  Engineering  for Biology & Medicine

Selected Publications

(In total >130 international journal papers, including 62 papers in journals with impact factor of >10; Google scholar h-index 56; Total citation > 8000 times; 18 journal covers & 5 Editor cover stories; the majority of papers appearing in field's top 10% journals; *Corresponding author)

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​Selected invited review papers

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1. X Chen*, Current and future technological advances in transdermal gene delivery, Advanced Drug Delivery Reviews, 127, 85-105, 2018. (3/261 in Pharmacology and Pharmacy)

2. X Chen*, WJ Zhang*, Diamond nanostructures for drug delivery, bioimaging, and biosensing, Chemical Society Reviews, 46, 734-760, 2017. (2/171 in Multidisciplinary Chemistry)

3. L Yan, Y Yang, WJ Zhang, X Chen*, Advanced materials and nanotechnology for drug delivery, Advanced Materials, 26(31), 5533-5540, 2014. (Back Cover) (8/285 in Multidisciplinary Materials Science; 5/171 in Multidisciplinary Chemistry)

4. L Yan, JF Zhang, CS Lee, X Chen*, Micro- and nanotechnologies for intracellular delivery, Small, 10(22), 4487-4504, 2014. (17/285 in Multidisciplinary Materials Science)

5. B He, Y Yang, MF Yuen, X Chen, CS Lee, WJ Zhang, Vertical nanostructure arrays by plasma etching for applications in biology, energy and electronics, Nano Today, 8(3), 265-289, 2013. (7/285 in Multidisciplinary Materials Science)

 

Selected latest publications

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1. Y Xue, B Lei, X Feng, M Ye, P Hazelton, Y Huang, X Fan, G Zhu, N Robertson, E Hosseini-Beheshti, X Chen*, A novel dye-sensitised solar cell based portable sensor for chemical detection, Sensors and Actuators B: Chemical, 403, 135123, 2024.

2. G Liu, Y Zhang, H Yao, Z Deng, S Chen, Y Wang, W Peng, G Sun, M Tse, X Chen, J Yue, Y. Peng, L Wang, G Zhu, An ultrasound-activatable platinum produrg for sono-sensitized chemotherapy, Science Advances, 9, eadg5964, 2023.​

3. Y Xue, X Ma, F Xue, S Roberts, G Zhu, Y Huang, X Fan, J Fan*, X Chen*, Temperature-derived purification gold nano-bipyramids for colorimetric detection of tannic acid, ACS Applied Nano Materials, 6(13), 11572-11580, 2023. 

4. Q Tan, S Zhao, T Xu, Q Wang, M Zhang, L Yan*, X Chen*, M Lan*, Inorganic nano-drug delivery systems for crossing the blood-brain barrier: Advances and challenges, Coordination Chemistry Reviews, 494, 215344, 2023.

5. X Feng, Y Xue, S Gonca, K Ji, M Zhang, FR Garcia Garcia, Y Huang, Q Li, K Kamenev, X Chen*, Ultrasmall superparamagnetic iron oxide nanoparticles for enhanced tumor penetration, Journal of Materials Chemistry B, 11, 3422-3433, 2023.

6. T Fan, L Yan, S He, Q Hong, F Ai, S He, T Ji, X Hu, E Ha, B Zhang, Z Li, H Zhang*, X Chen*, J Hu*, Biodistribution, degradability and clearance of 2D materials for their biomedical applications, Chemical Society Review, 2022, 51, 7732-7751.

7. L Yan, A Gopal, S Kashif, P Hazelton, M Lan*, W Zhang*, X Chen*, Metal organic frameworks for antibacterial applications, Chemical Engineering Journal, 435, 134975, 2022.

8. A Gopal, L Yan, S Kashif, T Munshi, RAL Vellaisamy, NH Voelcker*, X Chen*, Biosensors and point-of-care devices for bacterial detection: Rapid dianostics informing antibiotic therapy, Advanced Healthcare Materials, 11, 2101546, 2022.

9. Y Xue, X Feng, X Fan, G Zhu, J McLaughlan, W Zhang*, X Chen*, Extracellular vesicles for the diagnosis of cancers, Small Structures, 3, 2100096, 2022.

10. S Karaosmanoglu, Y Zhang, W Zhou, D Ouyang*, X Chen*, Synthesis of carrier-free paclitaxel-curcumin nanoparticles: The role of curcuminoids, Bioengineering, 9(12) 815, 2022.

11. Q Tan, S Zhao, T Xu, Q Wang, M Lan*, L Yan*, X Chen*, Getting drugs to the brain: Advances and prospects of organic nanoparticle delivery systems for assisting drugs to cross the blood-brain barrier, Journal of Materials Chemistry B, 10, 9314-9333, 2022.

12. L Yan*, J Li, A Gopal, SC Roberts, J Lin*, T Liu, T Munshi, X Zhang, X Chen*, Layered double hydroxide-silver-chlorin e6 nanocomposite for photo-chemo combination therapy to efficiently combat both Gram-positive and Gram-negative bacteria, Materials Today Communications, 30, 103101, 2022.

13. S Karaosmanoglu, M Zhou, B Shi, X Zhang*, GR Williams*, X Chen*, Carrier-free nanodrugs for safe and effective cancer treatment, Journal of Controlled Release, 329, 805-832, 2021.

14. M Zhang, X Chen*, N Radacsi, New tricks of old drugs: Repurposing non-chemo drugs and dietary phytochemicals as adjuvants in anti-tumor therapies, Journal of Controlled Release, 329, 96-120, 2021.

15. N Wang, Z Deng, Q Zhu, J Zhao, K Xie, P Shi, Z Wang, X Chen, F Wang, J Shi, G Zhu, An erythrocyte-delivered photoactivable oxaliplatin nanoprodrug for enhanced antitumor efficacy and immune response, Chemical Science, 12(43) 14353-14362, 2021.

16. M Koleoso, X Feng, Y Xue, Q Li, T Munshi, X Chen*, Micro/nanoscale magnetic robots for biomedical applications, Materials Today Bio, 8, 100085, 2020.

17. L Yan, S Gonca, G Zhu, W Zhang, X Chen*, Layered double hydroxides nanostructures and nanocomposites for biomedical applications, Journal of Materials Chemistry B, 7, 5583-5601, 2019.

18. X Feng, H Dixon, H Glen-Ravenhill, S Karaosmanoglu, Q Li, L Yan, X Chen*, Smart nanotechnologies to target tumor with deep penetration depth for efficient cancer treatment and imaging, Advanced Therapeutics, 1900093, 2019.

19. J Lin, J Li, A Gopal, T Munshi, Y Chu, J Wang, T Liu, B Shi, X Chen*, L Yan*, Synthesis of photo-excited Chlorin e6 conjugated silica nanoparticles for enhanced anti-bacterial efficiency to overcome methicillin-resistant Staphylococcus aureus, Chemical Communications, 55, 2656-2695, 2019.

20. JF Zhang, WD Nie, R Chen, J Chelora, YP Wan, X Cui, XH Zhang, WJ Zhang, X Chen, HY Xie, CS Lee, Green mass production of pure nanodrugs via an ice-template-assisted strategy, Nano Letters, 19, 2, 658-665, 2019.

21. X Chen*, Current and future technological advances in transdermal gene delivery, Advanced Drug Delivery Reviews, 127, 85-105, 2018.

22. N Wang, ZG Wang, ZF Xu, X Chen, G Zhu, A cisplatin-loaded immuno-chemotherapeutic nanohybird bearing immune checkpoint inhibitors for enhanced cervical cancer therapy, Angewandte Chemie International Edition, 57(13), 3426-3430, 2018. 

23. X Chen*, WJ Zhang*, Diamond nanostructures for drug delivery, bioimaging, and biosensing, Chemical Society Reviews, 46, 734-760, 2017.

24. SH Liu, Y Fu, GJ Li, L Li, HKW Law, X Chen*, F Yan*, Conjugated polymer for voltage-controlled release of molecules, Advanced Materials, 29(35), article number 1701733, 2017.

25. L Yan, MJ Zhou, XJ Zhang*, LB Huang, W Chen, VAL Roy, WJ Zhang*, X Chen*, A novel type of aqueous dispersible ultrathin layered double hydroxide nanosheets for in vivo bioimaging and drug delivery, ACS Applied Materials & Interfaces, 9(39), 34185-34193, 2017.

26. L Yan, X Chen*, ZG Wang, XJ Zhang, XY Zhu, MJ Zhou, W Chen, LB Huang, VAL Roy, PKN Yu, G Zhu, WJ Zhang*, Size controllable and surface tunable zeolitic imidazolate framework-8 (ZIF-8)-poly(acrylic acid sodium salt) (PAAS) nanocomposites for pH responsive drug release and enhanced in vivo cancer treatment, ACS Applied Materials & Interfaces, 9(38), 32990-33000, 2017.

27. L Yan, ZG Wang, X Chen*, XJ Gou, ZY Zhang, XY Zhu, MH Lan, W Chen, G Zhu, WJ Zhang*, Firmly anchored photosensitizer Chlorin e6 to layered double hydroxide nanosheets for highly efficient photodynamic therapy, Chemical Communications, 53, 2339-2342, 2017.

28. XY Nan, XJ Zhang*, YQ Liu, MJ Zhou, X Chen*, XH Zhang*, Dual-targeted multifunctional nanoparticles for magnetic resonance imaging guided cancer diagnosis and therapy, ACS Applied Materials & Interfaces, 9 (11), 9986-9995, 2017.

29. YQ Liu, XJ Zhang, MJ Zhou, XY Nan, X Chen, XH Zhang, Mitochondrial-targeting lonidamine-doxorubicin nanoparticles for synergistic chemotherapy to conquer drug resistance, ACS Applied Materials & Interfaces, 9 (50), 43498-43507, 2017.

30. XY Zhu, MF Yuen, FJ Ai, L Yan, Y Yang, KN Yu, G Zhu*, WJ Zhang*, X Chen*, Diamond- nanoneedle-array-facilitated intracellular delivery and the potential influence on cell physiology, Advanced Healthcare Materials, 5(10), 1157-1168, 2016. (Inside Cover)

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Previous representative research papers

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1. RR Xu, LM Huang, X Chen*, WJ Wei, XH Zhang, XJ Zhang*, Real-time imaging and tracking of ultrastable organic dye nanoparticles in living cells, Biomaterials, 93, 38-47, 2016.

2. XJ Zhang, JS Jie, W Deng, QX Shang, JC Wang, H Wang, X Chen, LM Huang, XH Zhang, Alignment and patterning of ordered small-molecule organic semiconductor micro/nanocrystals for device applications, Advanced Materials, 28(13), 2475-2503, 2016.

3. JF Zhang, YN Li, FF An, XH Zhang, X Chen, CS Lee, Preparation and size control of sub-100 nm pure nanodrugs, Nano Letters, 15(1) 313-318, 2015.

4. JF Zhang, XD Lin, XY Zhu, L Yan, SL Li, X Yang, P Shi, AL Rogach, GY Zhu, XH Zhang, X Chen, WJ Zhang, CS Lee, Self-monitoring and self-delivery of photosensitizer-doped nanoparticles for highly effective combination cancer therapy in vitro and in vivo, ACS Nano, 9(10), 9741-9756, 2015.

5. Y Wang, Y Yang, L Yan, SY Kwok, W Li, ZG Wang, XY Zhu, GY Zhu, WJ Zhang*, X Chen*, P Shi*, Poking cells for efficient vector-free intracellular delivery, Nature Communications, 5, article number: 4466, 2014.

6. J Yu, XJ Zhang*, XJ Hao, XH Zhang, MJ Zhou, CS Lee*, X Chen*, Near-infrared fluorescence imaging using organic dye nanoparticles, Biomaterials, 35, 3356-3364, 2014.

7. HQ Huang, R Chen, L Yan, YQ Zhao, WJ Zhang*, J Fan*, X Chen*, Graphitic carbon nitride solid films for selective and recyclable sensing of Cu2+ and Ag+ in water and serum, Chemical Communications, 50, 15415-15418, 2014.

8. L Yan, AP Raphael, XY Zhu, BL Wang, W Chen, T Tang, Y Deng, HJ Sant, G Zhu, KW Choy,  BK Gale, TW Prow, X Chen*, Nanocomposite strengthened dissolving microneedles for improved transdermal delivery to human skin, Advanced Healthcare Materials, 3(4), 555-564, 2014.

9. W Chen, C Wang, L Yan, LB Huang, XY Zhu, B Chen, HJ Sant, XR Niu, G Zhu, KN Yu, VAL Roy, BK Gale, X Chen*, Improved polyvinylpyrrolidone microneedle arrays with non-stoichimetric cyclodextrin, Journal of Materials Chemistry B, 2, 1699-1705, 2014.

10. L Yan, Y Wang, JH Li, S Kalytchuk, A Susha, SV Kershaw, F Yan, AL Rogach, X Chen*, Highly luminescent covalently bonded layered double hydroxide–fluorescent dye nanohybrids, Journal of Materials Chemistry C, 2, 4490-4494, 2014.

11. X Chen*, G Zhu*, Y Yang, B Wang, et al., A diamond nanoneedle array for potential high-throughput intracellular delivery, Advanced Healthcare Materials, 2(8), 1103-1107, 2013. (Front Cover, Cover Story)

12. L Yan, W Chen, XY Zhu, LB Huang, ZG Wang, GY Zhu, VAL Roy, KN Yu, X Chen*, Folic acid conjugated self-assembled layered double hydroxides nanoparticles for high-efficacy-targeted drug delivery, Chemical Communications, 49, 10938-10940, 2013.

13. X Chen, GJ Fernando, AP Raphael, et al., Rapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skin, Journal of Controlled Release, 158(1), 78-84, 2012.

14. X Chen, HJ Corbett, SR Yukiko, et al., Site-selectively coated, densely-packed microprojection array patches for targeted delivery of vaccines to skin, Advanced Functional Materials, 21(3), 464-473, 2011.

15. X Chen, GJ Fernando, ML Crichton, et al., Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilization, Journal of Controlled Release, 152(3), 349-355, 2011. (Front Cover and Editor Cover Story)

16. X Chen, AS Kask, ML Crichton, et al., Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays, Journal of Controlled Release, 148(3), 327-333, 2010.

17. X Chen*, JL Hutchison, PJ Dobson, G Wakefield, Tunning the internal structures of CdSeS nanoparticles by using different selenium and sulphur precursors, Materials Science and Engineering B, 166(1), 14-18, 2010.

18. X Chen, TW Prow, ML Crichton, et al., Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skin, Journal of Controlled Release, 139(3), 212-220, 2009. (Front Cover and Editor Cover Story)

19. X Chen*, JL Hutchison, PJ Dobson, G Wakefield, Highly luminescent monodisperse CdSe nanoparticles synthesized in aqueous solution, Journal of Materials Science, 44(1), 285-292, 2009.

20. X Chen*, JL Hutchison, PJ Dobson, G Wakefield, A one-step aqueous synthetic route to extremely small CdSe nanoparticles, Journal of Colloid and Interface Science, 319(1), 140-143, 2008.